HCID 18357191, compound → HCID 18357244, compound

HRID 1387000Notes

Reaction equation

HRID 1387000 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[C:10]=2[C:18]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])=[CH:22][CH:21]=2)=[O:19])=[CH:5][CH:4]=1>C1COCC1>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[C:10]=2[C:18]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH2:28][N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])=[CH:24][CH:25]=2)=[O:19])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 18357191HCID 18357191, compound

Product 1

HCID 18357244HCID 18357244, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By essentially following the procedure outlined in Example 1, part D, the title compound was prepared in 71% yield from 4-[2-(diethylamino)ethoxy]phenyl 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl ketone (Part A) as an orange foam following flash chromatography (SiO2; 5% TEA in THF).

Sources & evidence

ORD record
ord-41e6543e6d8343b692cf9f4126436b42
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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