HCID 54374393, compound → HCID 136016629, compound

HRID 1387214Notes

Reaction equation

HRID 1387214 reaction equation
[CH3:1][CH:2]([C:4]1[N:5]=[C:6]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[O:19]CC2C=CC=CC=2)[O:7][C:8]=1[O:9][CH2:10][CH3:11])[CH3:3]>C(OCC)(=O)C.[Pd]>[CH3:1][CH:2]([C:4]1[N:5]=[C:6]([C:12]2[C:13]([OH:19])=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])[O:7][C:8]=1[O:9][CH2:10][CH3:11])[CH3:3]

Participants

4

Reactant 1

HCID 54374393HCID 54374393, compound

Product 1

HCID 136016629HCID 136016629, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

0.4 g 4-(2-propyl)-5-ethoxy-2-(2-benzyloxy-6-chlorophenyl)oxazole was dissolved in 10 ml ethyl acetate. To the solution, 5% palladium/carbon in an amount of 0.11 g was further added, and the solution was stirred under hydrogen atmosphere for 15-30 min. at room temperature. The solution reacted was filtrated, then the filtrate was condensed under reduced pressure, affording the objective substance in an amount of 0.28 g.

Workup

  1. customThe solution reacted
  2. filtrationwas filtrated
  3. customcondensed under reduced pressure
  4. customaffording the objective substance in an amount of 0.28 g

Sources & evidence

ORD record
ord-a71156645ffa4277a0459a22425fb0d8
Source dataset
uspto-grants-2001_07
Patent number
US06268310B1

Reaction notes

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