huagongshe.com
HRID1387436

反应详情

EQUATION

反应方程式

HRID 1387436 的结构方程式

REACTANTS

反应物

3
结构：CC(C)=O
HCID180

Acetone

C3H6O

结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CCOC(=O)C[C@@H](c1ccc2c(c1)OCC2)N1CCC(CCCC2(C)OCCO2)C1=O
HCID15453768

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)C[C@@H](c1ccc2c(c1)OCC2)N1CCC(CCCC(C)=O)C1=O
HCID15453769

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A solution of 4-1 (600 mg, 1.4 mmol), p-TSA (20 mg) and acetone (50 mL) was heated at reflux for 4 hr. The cooled reaction mixture was diluted with EtOAc and then washed with sat. NaHCO3 and brine, dried (MgSO4), and concentrated to afford 4-2 as a colorless oil.

WORKUP

后处理

  1. temperatureat reflux for 4 hr
  2. customThe cooled reaction mixture
  3. washwashed with sat. NaHCO3 and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated