P-Cresol → HCID 11708331, compound

HRID 1387490Notes

Reaction equation

HRID 1387490 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[F:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Cl)=[CH:12][CH:11]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([F:9])=[CH:11][CH:12]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 2879P-CresolHCID 96024-Fluorobenzyl chloride

Product 1

HCID 11708331HCID 11708331, compound

Procedure

Alkylation of 4-methylphenol with 4-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-methyl-2-(4′-fluorobenzyl)phenol). This material was converted to compound 84 and compound 85 by theprocedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-0efbc313ae8f4e09a885169ca854d11b
Source dataset
uspto-grants-2001_07
Patent number
US06268392B1

Reaction notes

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