反应详情

5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole (10 g; 0.0304 mole) was suspended in ethyl acetate (100 ml) and cooled below 0° C. 3-chloroperoxybenzoic acid (5.25 g; 0.0304 mole) was added in such a manner that the temperature did not exceed 5° C. After completed addition it was left to crystallize for another half an hour at a temperature below 5° C. The product formed was filtered off, washed with ethyl acetate and dried in vacuo. Crude omeprazole (8.3 g; 79.1%) was obtained.

1. temperaturecooled below 0° C
2. customdid not exceed 5° C
3. additionaddition it
4. waitwas left
5. customto crystallize for another half an hour at a temperature below 5° C
6. customThe product formed
7. filtrationwas filtered off
8. washwashed with ethyl acetate
9. customdried in vacuo