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A solution of 6-(4-methylphenyl)-1-indanone (4.97 g) in THF (33 ml) was dropwise added to a refluxed mixture of 60% sodium hydride (3.26 g), potassium hydride (catalytic amount), dimethyl carbonate (6.65 ml) and THF (100 ml), and the mixture was refluxed for 6 hours. The reaction mixture was cooled to 0° C., and to the mixture was gradually added 2N hydrochloric acid (150 ml). The mixture was extracted with ethyl acetate, and the organic layer was washed with saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was separated and purified with column chromatography (ethyl acetate/toluene=1/3) to give a brown solid. The solid was dissolved in dichloromethane (100 ml) and to the mixture was added sodium boron hydride (391 mg) at 0° C. and then was dropwise added methanol (10 ml). The reaction mixture was stirred at 0° C. for 1.5 hours, and to the mixture was added water (500 ml). The mixture was extracted with ethyl acetate, and the organic layer was washed with saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in methanol (30 ml), and to the mixture was added 1N sodium hydroxide (40 ml). The mixture was refluxed for 2 hours and cooled to room temperature. To the mixture was added water, and the mixture was washed with diethylether. The aqueous layer was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was dissolved in Diglyme (30 ml), and to the mixture was added concentrated hydrochloric acid (6 ml). The mixture was stirred at 100° C. for 2 hours, and to the solution were added 0.5% sodium hydrogen carbonate solution (500 ml) and hexane(500 ml). The resulting precipitate was filtered to give 5-(4-methylphenyl)-indene-2-carboxylic acid (2.72 g) as brown crystals.

1. temperaturethe mixture was refluxed for 6 hours
2. extractionThe mixture was extracted with ethyl acetate
3. washthe organic layer was washed with saturated sodium chloride solution
4. dry with materialdried with anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue was separated
7. custompurified with column chromatography (ethyl acetate/toluene=1/3)
8. customto give a brown solid
9. extractionThe mixture was extracted with ethyl acetate
10. washthe organic layer was washed with saturated sodium chloride solution
11. dry with materialdried with anhydrous sodium sulfate
12. concentrationconcentrated under reduced pressure
13. dissolutionThe residue was dissolved in methanol (30 ml)
14. additionto the mixture was added 1N sodium hydroxide (40 ml)
15. temperatureThe mixture was refluxed for 2 hours
16. temperaturecooled to room temperature
17. additionTo the mixture was added water
18. washthe mixture was washed with diethylether
19. extractionextracted with ethyl acetate
20. washThe organic layer was washed with saturated sodium chloride solution
21. dry with materialdried with anhydrous sodium sulfate
22. concentrationconcentrated under reduced pressure
23. dissolutionThe residue was dissolved in Diglyme (30 ml)
24. additionto the mixture was added concentrated hydrochloric acid (6 ml)
25. stirringThe mixture was stirred at 100° C. for 2 hours
26. additionto the solution were added 0.5% sodium hydrogen carbonate solution (500 ml) and hexane(500 ml)
27. filtrationThe resulting precipitate was filtered