Dimethylformamide → HCID 18472442, compound

HRID 1387815Notes

Reaction equation

HRID 1387815 reaction equation
[Cl:1]CC1C=[CH:7][C:6]([NH:9][C:10]([C:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][C:16]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=4)=[CH:17][CH:18]=3)[CH:13]=2)=[O:11])=[CH:5][CH:4]=1.[CH2:29]([N:32]1[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1)[CH2:30][CH3:31].C(O[CH2:43][CH3:44])(=O)C.[CH3:45]N(C=O)C>>[Cl-:1].[CH3:28][C:25]1[CH:26]=[CH:27][C:22]([C:16]2[CH:15]=[C:14]3[C:19]([CH2:20][CH2:21][C:12]([C:10]([NH:9][C:6]4[CH:5]=[CH:4][C:30]([CH2:29][N+:32]5([CH2:45][CH2:43][CH3:44])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]5)=[CH:31][CH:7]=4)=[O:11])=[CH:13]3)=[CH:18][CH:17]=2)=[CH:23][CH:24]=1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 12097447HCID 12097447, compoundHCID 18472361N-[4-(chloromethyl)phenyl]-7-(4-methylphenyl)-3,4-dihydronaphthalene-2-carboxamide

Product 1

HCID 18472442HCID 18472442, compound

Procedure

In DMF (3 ml) was dissolved N-[4-(chloromethyl)-phenyl]-7-(4-methylphenyl)-3,4-dihydronaphthalene-2-carboxamide (150 mg), and to the mixture was added 1-propylperhydroazepine (109 mg). The mixture was stirred at room temperature for 15 hours. To the reaction mixture was added ethyl acetate (100 ml), and the resulting precipitate was filtered to give 1-[4-[7-(4-methylphenyl)-3,4-dihydronaphthalene-2-carboxamido]benzyl]-1-propyl-perhydroazepinium chloride (Compound 38) (163 mg) as colorless crystals.

Workup

  1. filtrationthe resulting precipitate was filtered

Sources & evidence

ORD record
ord-5fcd5227cc1947a28b5dab48f5217bdf
Source dataset
uspto-grants-2001_07
Patent number
US06268354B1

Reaction notes

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