Formaldehyde → HCID 54295183, compound

HRID 1388151Notes

Reaction equation

HRID 1388151 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH:5]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:6](O)=O)[CH3:2].C=O.N1CCCCC1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:21])[C:5](=[CH2:6])[CH2:9][CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)[CH3:2]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8082PiperidineHCID 54183825HCID 54183825, compound

Product 1

HCID 54295183HCID 54295183, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

82.3 g of 4-(3-cyclohexylpropyloxy)-2-methylenebutyric acid ethyl ester, in the form of a colourless oil, which is purified by chromatography on silica gel (migrating agent: chloroform), are obtained by the procedure described in Example (1b) from 103.6 g of 2-(3-cyclohexylpropyloxy)-ethylmalonic acid ethyl ester, 11 g of paraformaldehyde, 105 ml of pyridine and 2.9 g of piperidine.

Workup

  1. custom82.3 g of 4-(3-cyclohexylpropyloxy)-2-methylenebutyric acid ethyl ester, in the form of a colourless oil, which is purified by chromatography on silica gel (migrating agent: chloroform)
  2. customare obtained by the procedure

Sources & evidence

ORD record
ord-dad19fc5f46b4d35a0182eb86525da29
Source dataset
uspto-grants-1984_02
Patent number
US04430339

Reaction notes

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