Sodium Hydroxide → HCID 3062094, compound

HRID 1388795Notes

Reaction equation

HRID 1388795 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:18](=O)[CH2:19][CH:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:9]2)=[CH:4][CH:3]=1.O.NN.[OH-].[Na+]>C(O)COCCO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH2:18][CH2:19][CH:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 3062075HCID 3062075, compound

Product 1

HCID 3062094HCID 3062094, compoundYield 34.7%

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

The operation is as in Example 18, starting from 13.5 g of 1-(7-chloro-2-phenyl-4-quinolyl)-2-(4-piperidyl)-ethanone prepared as indicated in Example 10, 6 g of 98% hydrazine hydrate and 2.4 g of sodium hydroxide in 200 ml of diethylene glycol. 4.5 g of 7-chloro-2-phenyl-4-[2-(4-piperidyl)-ethyl]-quinoline are obtained, the monohydrochloride of which, formed by the action of hydrochloric acid in isopropanol, melts at 195° C.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-c5a642deddd14bc28851358612ebc7de
Source dataset
uspto-grants-1984_02
Patent number
US04433150

Reaction notes

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