Methane → 1-Amidino-4-piperidinepropionic acid hydrochloride

HRID 1388841Notes

Reaction equation

HRID 1388841 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH2:6][CH2:5]1)(=[NH:3])[NH2:2].C.[ClH:16]>>[ClH:16].[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH2:6][CH2:5]1)(=[NH:2])[NH2:3]

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 155835111-Amidino-4-piperidinepropionic acid

Product 1

HCID 155835121-Amidino-4-piperidinepropionic acid hydrochloride

Procedure

2.0 g of 1-amidino-4-piperidinepropionic acid prepared in Example 1 was dissolved in 15 ml of 1 N hydrochloric acid. To the solution was added 0.2 g of activated charcoal, and the resulting mixture was stirred for 30 minutes. After removal of activated charcoal by filtration, the filtrate was concentrated under reduced pressure. Acetone was added to the residue to give crystals which were then washed with acetone and further with ether and dried to obtain 1.7 g of 1-amidino-4-piperidinepropionic acid hydrochloride as prisms having a melting point of 199.5° to 202° C.

Workup

  1. customAfter removal of activated charcoal
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. additionAcetone was added to the residue
  5. customto give crystals which
  6. washwere then washed with acetone and further with ether
  7. customdried

Sources & evidence

ORD record
ord-de92d9f329ca4115b851fa250e3ad209
Source dataset
uspto-grants-1984_02
Patent number
US04433152

Reaction notes

Loading…