Hydrochloric Acid → HCID 13277457, compound

HRID 1388895Notes

Reaction equation

HRID 1388895 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[C:14]([O:19][CH3:20])=[N:15][CH:16]=[N:17][CH:18]=1)=[S:11])(=O)C1C=CC=CC=1.Cl>CC[O-].[Na+]>[CH3:20][O:19][C:14]1[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[CH:18][N:17]=[CH:16][N:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20468975HCID 20468975, compound

Product 1

HCID 13277457HCID 13277457, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 2723922Sodium ethoxideSolvent

Procedure

6.0 g N-benzoyl-N'-(4-methoxy-5-pyrimidyl)-thiourea are dissolved in 120 ml sodium ethylate solution (0.8 g sodium). After 1 hour, the solution is neutralized with diluted hydrochloric acid. The mixture is concentrated and the residue is washed with water and recrystallized from a methanol/water mixture. 2.3 g N-(4-methoxy-5-pyrimidyl)-thiourea having a melting point of 182° to 183° C. (decomp.) are obtained.

Workup

  1. concentrationThe mixture is concentrated
  2. washthe residue is washed with water
  3. customrecrystallized from a methanol/water mixture

Sources & evidence

ORD record
ord-757d0b47038a446a80be6f970a3cab2b
Source dataset
uspto-grants-1984_02
Patent number
US04434167

Reaction notes

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