N-Methylbenzylamine → N-benzyl-N-methylpiperidine-4-carboxamide

HRID 1389154Notes

Reaction equation

HRID 1389154 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17](Cl)=[O:18])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[CH3:20][NH:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:20][N:21]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]([CH:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)=[O:18]

Participants

3

Reactant 2

HCID 7669N-MethylbenzylamineHCID 2776270Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate

Product 1

HCID 5103038N-benzyl-N-methylpiperidine-4-carboxamide

Procedure

This compound was prepared similarly to Preparation C starting from 1-benzyloxycarbonylpiperidine-4-carboxylic acid chloride and N-methylbenzylamine, and was used directly in Example 10. This intermediate was characterised as the hydrochloride salt, m.p. 175°-176°.

Workup

  1. customThis compound was prepared similarly to Preparation C

Sources & evidence

ORD record
ord-0399a0cb0319432c8d68d929a598f5c5
Source dataset
uspto-grants-1981_01
Patent number
US04243666

Reaction notes

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