Epichlorohydrin → HCID 20298518, compound

HRID 1389173Notes

Reaction equation

HRID 1389173 reaction equation
[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[CH3:6][S:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14].[CH2:15]([NH2:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>>[ClH:2].[CH3:6][S:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][CH2:1][CH:3]([OH:5])[CH2:4][NH:23][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 3

HCID 7835EpichlorohydrinHCID 8143OctylamineHCID 61261o-(Methylthio)phenol

Product 1

HCID 20298518HCID 20298518, compoundYield 18%

Procedure

Reaction of the epichlorhydrin derivative of 2-(methylthio)phenol (14 g., 0.071 mole) with n-octylamine (9.04 g., 0.07 mole) according to the procedure of Example 2(b) and crystallization of the crude product from methanol-ether affords an 18% yield of analytically pure 1-[2-(methylthio)phenoxy]-3-(octylamino)-2-propanol hydrochloride, m.p. 105.5°-107.5° (corr.).

Workup

  1. customaccording to the procedure of Example 2(b) and crystallization of the crude product from methanol-ether

Sources & evidence

ORD record
ord-604b307602064f39ad8000ef7f16102c
Source dataset
uspto-grants-1981_01
Patent number
US04243681

Reaction notes

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