2,4-Dichlorobenzoyl chloride → HCID 20298487, compound

HRID 1389199Notes

Reaction equation

HRID 1389199 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7]CC)=[O:6].[CH3:10][C:11]([NH2:15])([CH3:14])[CH2:12][CH3:13].[Cl:16][C:17]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:18]=1[C:19](Cl)=[O:20]>>[Cl:16][C:17]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:18]=1[C:19]([CH:4]([CH2:3][CH2:2][NH:15][C:11]([CH3:14])([CH3:10])[CH2:12][CH3:13])[C:5]([OH:7])=[O:6])=[O:20]

Participants

4

Reactant 3

HCID 666452,4-Dichlorobenzoyl chlorideHCID 689862-Butanamine, 2-methyl-HCID 76300Ethyl 4-bromobutyrate

Product 1

HCID 20298487HCID 20298487, compound

Procedure

Analogously to Example 1, ethyl N-(2,4-dichloro)-benzoyl-4-[(1,1-dimethylpropyl)amino]butyrate (M.P. 75° to 77°) is obtained by reacting the reaction product of ethyl 4-bromobutyrate and 1,1-dimethylpropylamine with 2,4-dichlorobenzoyl chloride, the saponification of which yields 2,4-dichlorobenzoyl-4-[(1,1-dimethylpropyl)amino]-butyric acid (M.P. 124° to 126°).

Sources & evidence

ORD record
ord-faed4a1edccf4ea29b44add72d8c4808
Source dataset
uspto-grants-1981_01
Patent number
US04243678

Reaction notes

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