反应详情

In 30 ml of ether was dissolved 2.5 g of 5-acetyl-3-methylisoxazole. While gaseous hydrogen chloride was passed through the resultant solution with stirring, a solution of 4.5 g of amyl nitrite in 10 ml of ether was dropped thereinto. After a further one hour stirring at room temperature after completion of said dropwise addition, the resulting precipitate was isolated by filtration. Recrystallization from chloroform gave 1.0 g of (3-methylisoxazole-5-yl)glyoxal-2-oxim having m.p. of 179° C.-180° C. Yield, 27%.

1. stirringAfter a further one hour stirring at room temperature after completion
2. additionaddition
3. customthe resulting precipitate was isolated by filtration
4. customRecrystallization from chloroform