Hydrochloric Acid → HCID 20296596, compound

HRID 1389475Notes

Reaction equation

HRID 1389475 reaction equation
[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[O:5][CH2:6][CH:7]([OH:20])[CH2:8][N:9]1[CH2:19][CH2:18][C:12]2([O:16][C:15](=[O:17])[NH:14][CH2:13]2)[CH2:11][CH2:10]1.[ClH:25].C(OCC)C>CO>[ClH:25].[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[O:5][CH2:6][CH:7]([OH:20])[CH2:8][N:9]1[CH2:19][CH2:18][C:12]2([O:16][C:15](=[O:17])[NH:14][CH2:13]2)[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 130166488-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Product 1

HCID 20296596HCID 20296596, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1 g of 8-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one in 5 ml methanol is added 10 ml, 3% hydrochloric acid in methanol. Addition of 200 ml diethyl ether followed by filtration affords 8-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride, mp indefinite.

Workup

  1. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-438539056a1f44889abdbee608915353
Source dataset
uspto-grants-1981_01
Patent number
US04244961

Reaction notes

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