反应详情

59 g of sodium 2-(2-methoxyethoxy)-5-nitrobenzenesulfonate prepared as described in Synthesis Example 1 was added to a mixture of 200 ml of acetone and 75 ml of phosphorous oxychloride. 75 ml of N,N-dimethylacetamide was added dropwise to the mixture with stirring while the reaction mixture was maintained at 30° to 40° C. After completion of the addition, the mixture was allowed to stand with stirring until it cooled to room temperature. The reaction mixture was then poured into 600 ml of ice water, stirred for 30 minutes and the crystals thus precipitated were collected by filtration. The crystals were washed with 100 ml of water and air-dried. Yield: 56 g. Melting Point: 74° to 74.5° C.

1. customas described in Synthesis Example 1
2. temperaturewas maintained at 30° to 40° C
3. additionAfter completion of the addition
4. stirringwith stirring until it
5. stirringstirred for 30 minutes
6. customthe crystals thus precipitated
7. filtrationwere collected by filtration
8. washThe crystals were washed with 100 ml of water
9. customair-dried