1,1'-Carbonyldiimidazole → HCID 178454932, compound

HRID 1390010Notes

Reaction equation

HRID 1390010 reaction equation
[CH2:1]([S:5][C:6]1[CH:15]=[CH:14][C:13]2[NH:12][C:11]3=[CH:16][C:17]([C:19]([OH:21])=O)=[N:18][N:10]3[C:9](=[O:22])[C:8]=2[CH:7]=1)[CH2:2][CH2:3][CH3:4].C(N1C=CN=C1)(N1C=CN=C1)=O.O.[NH2:36][C:37]1[NH:41][N:40]=[N:39][N:38]=1>CN(C=O)C>[CH2:1]([S:5][C:6]1[CH:15]=[CH:14][C:13]2[NH:12][C:11]3=[CH:16][C:17]([C:19]([NH:36][C:37]4[NH:41][N:40]=[N:39][N:38]=4)=[O:21])=[N:18][N:10]3[C:9](=[O:22])[C:8]=2[CH:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 178454933HCID 178454933, compoundHCID 178509300HCID 178509300, compound

Product 1

HCID 178454932HCID 178454932, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 4,9-dihydro-7-butylthio-9-oxo-pyrazolo-[5,1-b]quinazoline-2-carboxylic acid (1.9 g; 6 mmole), DMF (25 ml), 1,1'-carbonyl-diimidazole (2.19 g; 13.5 mmole) and 5-amino-1H-tetrazole, monohydrate (0.70 g; 6.8 mmole), following the procedure of Example 3, there is obtained 4,9-dihydro-7-butylthio-9-oxo-N-1H-tetrazol-5-yl-pyrazolo[5,1-b]quinazoline-2-carboxamide, with 1H-imidazole (3:1) (0.4 g); mp 285° (d).

Sources & evidence

ORD record
ord-0b9e2d0ec50646c0ac18a6e703a3c018
Source dataset
uspto-grants-1981_01
Patent number
US04247555

Reaction notes

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