1,1'-Carbonyldiimidazole → HCID 178493410, compound

HRID 1390011Notes

Reaction equation

HRID 1390011 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[NH:11][C:10]3=[CH:13][C:14]([C:16]([OH:18])=O)=[N:15][N:9]3[C:8](=[O:19])[C:7]=2[CH:6]=[C:5]([O:20][CH3:21])[CH:4]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.O.[NH2:35][C:36]1[NH:40][N:39]=[N:38][N:37]=1>CN(C=O)C>[CH3:1][O:2][C:3]1[C:12]2[NH:11][C:10]3=[CH:13][C:14]([C:16]([NH:35][C:36]4[NH:40][N:39]=[N:38][N:37]=4)=[O:18])=[N:15][N:9]3[C:8](=[O:19])[C:7]=2[CH:6]=[C:5]([O:20][CH3:21])[CH:4]=1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 178493411HCID 178493411, compoundHCID 178509300HCID 178509300, compound

Product 1

HCID 178493410HCID 178493410, compoundYield 43.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 4,9-dihydro-5,7-dimethoxy-9-oxo-pyrazolo-[5,1-b]quinazoline-2-carboxylic acid (1.54 g; 5 mmole), DMF (300 ml), 1,1'-carbonyldiimidazole (1.8 g; 11 mmole) and 5-amino-1H-tetrazole, monohydrate (0.52 g; 5 mmole), following the procedure of Example 3, there is obtained 4,9-dihydro-5,7-dimethoxy-9-oxo-N-1H-tetrazol-5-yl-pyrazolo-[5,1-b]quinazoline-2-carboxamide (0.78 g); mp 338°-342° (d).

Sources & evidence

ORD record
ord-43ed1e192fb943759c3fa53986d0f2e0
Source dataset
uspto-grants-1981_01
Patent number
US04247555

Reaction notes

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