Dimethylformamide → HCID 178504591, compound

HRID 1390013Notes

Reaction equation

HRID 1390013 reaction equation
[CH3:1][S:2]([C:4]1[CH:13]=[CH:12][C:11]2[NH:10][C:9]3=[CH:14][C:15]([C:17]([OH:19])=O)=[N:16][N:8]3[C:7](=[O:20])[C:6]=2[CH:5]=1)=[O:3].CN(C=O)C.C(N1C=CN=C1)(N1C=CN=C1)=O.O.[NH2:39][C:40]1[NH:44][N:43]=[N:42][N:41]=1>N1C=CC=CC=1>[CH3:1][S:2]([C:4]1[CH:13]=[CH:12][C:11]2[NH:10][C:9]3=[CH:14][C:15]([C:17]([NH:39][C:40]4[NH:44][N:43]=[N:42][N:41]=4)=[O:19])=[N:16][N:8]3[C:7](=[O:20])[C:6]=2[CH:5]=1)=[O:3]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 682631,1'-CarbonyldiimidazoleHCID 178504592HCID 178504592, compoundHCID 178509300HCID 178509300, compound

Product 1

HCID 178504591HCID 178504591, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

From 4,9-dihydro-7-(methylsulfinyl)-9-oxo-pyrazolo-[5,1-b]quinazoline-2-carboxylic acid (1.40 g; 5 mmole), DMF (50 ml), 1,1'-carbonyl-diimidazole (2.43 g; is mmole) and 5-amino-1-H-tetrazole, monohydrate (0.62 g; 6 mmole), following the procedure of Example 3, there is obtained 4,9-dihydro-7-(methylsulfinyl)-9-oxo-N-1H-tetrazol-5-yl-pyrazolo[5,1-b]quinazoline-2-carboxamide with pyridine (4:3), mp>350°; after crystallization from pyridine-ether.

Sources & evidence

ORD record
ord-642dd4f2a5ae4b71ac40142e33656d79
Source dataset
uspto-grants-1981_01
Patent number
US04247555

Reaction notes

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