Carbon Dioxide → 2-(4-Fluoro-1-piperidylmethyl)propenenitrile

HRID 1390111Notes

Reaction equation

HRID 1390111 reaction equation
[F:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8]([CH2:10][C:11](O)=O)#[N:9].[C:14](=O)=O.C(=O)(O)[O-].[Na+]>O.O1CCOCC1>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:14][C:10](=[CH2:11])[C:8]#[N:9])[CH2:4][CH2:3]1

Participants

7

Reactant 4

HCID 280Carbon DioxideHCID 9740Cyanoacetic acidHCID 516892Sodium BicarbonateHCID 27591594-Fluoropiperidine

Product 1

HCID 130410342-(4-Fluoro-1-piperidylmethyl)propenenitrile

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 312751,4-DioxaneSolvent

Conditions

Temperature
65 °C

Procedure

4-Fluoropiperidine (0.7 g., 0.005 mole) was dissolved in a mixture of 3 ml. of dioxane and 2 ml. of water containing cyanoacetic acid (0.43 g., 0.005 mole). The solution was heated to 65° C. and carbon dioxide evolution began. It was maintained at 60°-65° C. for 21/2 hours and allowed to stand overnight. A solid gummy residue, 1 gm., was obtained upon stripping in a bath at 55° C. and at 1 mm. It was taken up in a small amount of water, made alkaline with sodium bicarbonate and extracted with ether. The organic layer was water washed and dried over anhydrous sodium sulfate. After solvent stripping, the product was obtained as a colorless oil, 0.7 g., of analytical purity.

Workup

  1. temperatureIt was maintained at 60°-65° C. for 21/2 hours
  2. custom, was obtained
  3. customupon stripping in a bath at 55° C. and at 1 mm
  4. extractionextracted with ether
  5. washwashed
  6. dry with materialdried over anhydrous sodium sulfate
  7. customAfter solvent stripping, the product was obtained as a colorless oil, 0.7 g

Sources & evidence

ORD record
ord-72ea4d2695c645e3be5bf7802461d22a
Source dataset
uspto-grants-1981_01
Patent number
US04247700

Reaction notes

Loading…