Hydrochloric Acid → HCID 21295110, compound

HRID 1390205Notes

Reaction equation

HRID 1390205 reaction equation
[CH2:1]([CH:3]1[O:7]C=[N:5][CH:4]1[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:2].C(N(CC)CC)C.Cl>O>[NH2:5][CH:4]([CH:3]([OH:7])[CH2:1][CH3:2])[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 22748565HCID 22748565, compound

Product 1

HCID 21295110HCID 21295110, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Ethyl 5-ethyl-2-oxazoline-4-carboxylate (10.3 g), water (1.62 ml) and triethylamine (0.086 ml) were stirred at 100° C. for 3 hours. To this mixture was added 5N HCl (26 ml) and the mixture diluted to 100 ml with water, washed twice with methylene chloride and brought to pH 10 with 50% sodium hydroxide solution. The solution was extracted with methylene chloride (6 × 30 ml), dried and evaporated to yield the racemic title compound (e11) (9.4 g).

Workup

  1. washwashed twice with methylene chloride
  2. extractionThe solution was extracted with methylene chloride (6 × 30 ml)
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-b5f4e1c723b2493fb9f739a57f353b5f
Source dataset
uspto-grants-1979_02
Patent number
US04138403

Reaction notes

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