Hydrochloric Acid → HCID 22748499, compound

HRID 1390225Notes

Reaction equation

HRID 1390225 reaction equation
[NH2:1][CH:2]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][CH2:12][CH2:11][C:10]=2[CH:14]=1)[C:3]([OH:5])=[O:4].O.[C:16](Cl)(=[O:18])[CH3:17].Cl>[OH-].[Na+].CCOCC.C(OCC)(=O)C>[C:16]([NH:1][CH:2]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][CH2:12][CH2:11][C:10]=2[CH:14]=1)[C:3]([OH:5])=[O:4])(=[O:18])[CH3:17]

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6367Acetyl chlorideHCID 205312232-Amino-2-(2,3-dihydro-1-benzofuran-5-yl)acetic acid

Product 1

HCID 22748499HCID 22748499, compound

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolventHCID 14798Sodium HydroxideSolvent

Procedure

α-Amino(2,3-dihydro-5-benzofuranyl)acetic acid (10 mmole) is dissolved in 25 ml of water containing 20 mmole of sodium hydroxide. The temperature is maintained at 10° C. while 10.5 mmole of acetyl chloride in 10 ml of ether is added over a period of 10 minutes. The reaction mixture is stirred for 20 minutes. Ethyl acetate is added and the pH is adjusted to 2 with hydrochloric acid. The layers are separated, the organic layer is dried over magnesium sulfate, filtered and evaporated to give the title compound.

Workup

  1. additionis added over a period of 10 minutes
  2. customThe layers are separated
  3. dry with materialthe organic layer is dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-6724b2e3a42c47ce810d1b6eba7b62a7
Source dataset
uspto-grants-1979_02
Patent number
US04138397

Reaction notes

Loading…