反应详情

A mixture of 13.6 parts of 2-bromo-2',4'-dichloroacetophenone, 18 parts of 3-(6-bromo-2-napthyloxy)-1,2-propanediol, 3 parts of p-toluenesulfonic acid, 80 parts of n-butanol and 180 parts of benzene is stirred and refluxed for 24 hours with water-separator. The reaction mixture is evaporated. The residue is dissolved in chloroform and the solution is stirred with silica gel for one hour. The latter is filtered off and the filtrate is evaporated. The residue is crystallized twice: first from diisopropylether and then from dibutylether, yielding A 2-(bromomethyl)-4-(6-bromo-2-naphthyloxymethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane.

1. customThe reaction mixture is evaporated
2. dissolutionThe residue is dissolved in chloroform
3. stirringthe solution is stirred with silica gel for one hour
4. filtrationThe latter is filtered off
5. customthe filtrate is evaporated
6. customThe residue is crystallized twice