反应详情

A mixture of 106 g of benzaldehyde, 89 g of 2-amino-2-methyl-1-propanol, 2 ml of glacial acetic acid and 500 ml of benzene is heated for 3 hours under reflux, using a water separator. After completion of the reaction, the mixture is evaporated and the residue is dissolved in 2 liters of ethanol. After adding a total of 76 g of sodium borohydride in portions over the course of 2-3 hours, continuing to stir the mixture overnight at room temperature, and working up in the usual manner, 2-benzylamino-2-methyl-1-propanol is obtained, which melts at 50°-55° C. after crystallisation from ether.

1. temperatureis heated for 3 hours
2. temperatureunder reflux
3. customAfter completion of the reaction
4. customthe mixture is evaporated
5. dissolutionthe residue is dissolved in 2 liters of ethanol
6. additionAfter adding a total of 76 g of sodium borohydride in portions over the course of 2-3 hours