HCID 70605513, compound → HCID 70604765, compound

HRID 1390727Notes

Reaction equation

HRID 1390727 reaction equation
C([O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH2:23][O:24]C(=O)C)[C:7](=[CH:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[O:28][C:29](=[O:31])[CH3:30])[CH2:6]1)(=O)C>CO.C(=O)([O-])[O-].[K+].[K+].O>[C:29]([O:28][C@H:14]1[CH2:13][CH2:12][C@H:11]2[C@H:10]3[C@H:19]([CH2:18][CH2:17][C@:15]12[CH3:16])[C@:20]1([CH2:23][OH:24])[C:7]([CH2:6][C@@H:5]([OH:4])[CH2:22][CH2:21]1)=[CH:8][CH2:9]3)(=[O:31])[CH3:30]

Participants

5

Reactant 1

HCID 70605513HCID 70605513, compound

Product 1

HCID 70604765HCID 70604765, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 11430Potassium CarbonateSolvent

Procedure

A solution of 5-androstene-3β,17β,19-triol triacetate in methanol and potassium carbonate in water is combined and stirred at room temperature for a period of about 2 hours. The solution is poured onto water and the solid which forms is collected by filtration. Crystallization of this solid from an acetone solution yields 5-androstene-3β,17β,19-triol 17-acetate.

Workup

  1. additionThe solution is poured onto water
  2. filtrationthe solid which forms is collected by filtration
  3. customCrystallization of this solid from an acetone solution

Sources & evidence

ORD record
ord-68069eb63cbb4f9fa78e567fdaaf9c46
Source dataset
uspto-grants-1979_02
Patent number
US04139617

Reaction notes

Loading…