反应详情

19-Hydroxy-1α,4α-dimethyl-5-androstene-3,17-dione is added to a mixture containing dimethylsulfoxide, benzene, pyridine, trifluoroacetic acid and N,N-dicyclohexylcarbodiimide and allowed to react for about 12 hours at room temperature. Ethyl acetate is added and the reaction mixture is filtered, extracted with a cold solution of sodium bicarbonate, washed with water, and dried over magnesium sulfate. After evaporation of the volatile solvents at room temperature under reduced pressure, the residue which remains is crystallized from an ether-pentane mixture to yield 1α,4α-dimethyl-5-androstene-3,17,19-trione.

1. customto react for about 12 hours at room temperature
2. filtrationthe reaction mixture is filtered
3. extractionextracted with a cold solution of sodium bicarbonate
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. customAfter evaporation of the volatile solvents at room temperature under reduced pressure
7. customthe residue which remains is crystallized from an ether-pentane mixture