Acetic Anhydride → HCID 21332184, compound

HRID 1390949Notes

Reaction equation

HRID 1390949 reaction equation
[CH3:1][N:2]1[C:6]2[C:7]3[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][C:8]=3[S:9][C:5]=2[C:4]([NH2:15])=[N:3]1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>O1CCCC1>[CH3:1][N:2]1[C:6]2[C:7]3[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][C:8]=3[S:9][C:5]=2[C:4]([NH:15][C:16](=[O:18])[CH3:17])=[N:3]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 70524951HCID 70524951, compound

Product 1

HCID 21332184HCID 21332184, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 0.1 mole of 1,6-dimethyl-1H-(1)-benzothieno[3,2-c]pyrazol-3-amine and 30.0 g. of acetic anhydride in 180 ml. of tetrahydrofuran was heated under reflux for 1 hour. The reaction mixture was then cooled to 20° C. and the precipitate which formed was collected by filtration. Recrystallization from N,N-dimethyl formamide/water gave N-(1,6-dimethyl-1H-(1)benzothieno-[3,2-c]pyrazol-3-yl)acetamide, m.p. 253°-255° C.

Workup

  1. temperatureunder reflux for 1 hour
  2. customthe precipitate which formed
  3. filtrationwas collected by filtration
  4. customRecrystallization from N,N-dimethyl formamide/water

Sources & evidence

ORD record
ord-d09b710d913b467f8bd398355339f922
Source dataset
uspto-grants-1979_02
Patent number
US04140785

Reaction notes

Loading…