Hydrogen Bromide → HCID 178481930, compound

HRID 1390950Notes

Reaction equation

HRID 1390950 reaction equation
C[O:2][C:3]1[C:8]([O:9]C)=[CH:7][C:6]2[C:11]3[N:12]([CH3:18])[N:13]=[C:14]([NH2:17])[C:15]=3[S:16][C:5]=2[CH:4]=1.Br.[OH-].[NH4+]>O>[OH:2][C:3]1[C:8]([OH:9])=[CH:7][C:6]2[C:11]3[N:12]([CH3:18])[N:13]=[C:14]([NH2:17])[C:15]=3[S:16][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 14923Ammonium HydroxideHCID 21332195HCID 21332195, compound

Product 1

HCID 178481930HCID 178481930, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.1 mole of 6,7-dimethoxy-1-methyl-1H-(1)benzothieno[3,2-c]pyrazol-3-amine in 300 ml. of 48% aqueous hydrobromic acid was refluxed for 3 hours. The warm reaction mixture was poured into 1 liter of water and the aqueous mixture was adjusted to pH 7 using concentrated ammonium hydroxide solution. The precipitate which formed was removed by filtration and recrystallized from N,N-dimethyl formamide/water to give 6,7-dihydroxy-1-methyl-1H-(1)benzothieno[3,2-c]pyrazol-3-amine, m.p. 305°-307° C.

Workup

  1. customThe warm reaction mixture
  2. customThe precipitate which formed
  3. customwas removed by filtration
  4. customrecrystallized from N,N-dimethyl formamide/water

Sources & evidence

ORD record
ord-14f8eb0244de4f5ebef88ef7cd0b2e8b
Source dataset
uspto-grants-1979_02
Patent number
US04140785

Reaction notes

Loading…