4-Nitrobenzyl chloride → HCID 21331879, compound

HRID 1390980Notes

Reaction equation

HRID 1390980 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl.C([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:17]1)C.[CH2:28](N(CC)CC)[CH3:29]>>[CH2:28]([C:25]1[CH:24]=[CH:23][C:22]([N:19]2[CH2:18][CH2:17][N:16]([CH2:8][C:7]3[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:21][CH2:20]2)=[CH:27][CH:26]=1)[CH3:29]

Participants

4

Reactant 3

HCID 74824-Nitrobenzyl chlorideHCID 8471TriethylamineHCID 70609133HCID 70609133, compound

Product 1

HCID 21331879HCID 21331879, compound

Procedure

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with p-ethylphenylpiperazine dihydrochloride in the presence of triethylamine to give 1-(p-ethylphenyl)-4-(p-nitrobenzyl)piperazine.

Sources & evidence

ORD record
ord-4bf32115666a46649df0be200514400d
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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