4-Nitrobenzyl chloride → HCID 782285, compound

HRID 1390983Notes

Reaction equation

HRID 1390983 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1>C(N(CC)CC)C>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([N:22]2[CH2:27][CH2:26][N:25]([CH2:8][C:7]3[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 814291-(3-Methoxyphenyl)piperazine dihydrochloride

Product 1

HCID 782285HCID 782285, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with 4-(m-methoxyphenyl)piperazine dihydrochloride in the presence of triethylamine to give 1-(m-methoxyphenyl)-4-(p-nitrobenzyl)piperazine.

Sources & evidence

ORD record
ord-c74653731b6e41aca839d731b71918a6
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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