4-Nitrobenzyl chloride → HCID 21331835, compound

HRID 1391014Notes

Reaction equation

HRID 1391014 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>C(N(CC)CC)C>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[N:22]1[CH2:23][CH2:24][N:25]([CH2:8][C:7]2[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[CH2:26][CH2:27]1

Participants

4

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 27581871-(2,5-dichlorophenyl)piperazine Dihydrochloride

Product 1

HCID 21331835HCID 21331835, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with (2,5-dichlorophenyl)piperazine dihydrochloride in the presence of triethylamine to give 1-(2,5-dichlorophenyl)-4-(p-nitrobenzyl)piperazine.

Sources & evidence

ORD record
ord-1909fe17fa9e4f34917abdb162263089
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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