4-Nitrobenzyl chloride → HCID 764809, compound

HRID 1391017Notes

Reaction equation

HRID 1391017 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.Cl.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:17][CH:16]=1>C(N(CC)CC)C>[F:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[CH2:26][CH2:25][N:24]([CH2:8][C:7]3[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:23][CH2:22]2)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 74824-Nitrobenzyl chlorideHCID 162119161-(4-Fluorophenyl)piperazine dihydrochloride

Product 1

HCID 764809HCID 764809, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 1A, p-nitrobenzyl chloride is reacted with 1-(p-fluorophenyl)piperazine dihydrochloride in the presence of triethylamine to give 1-(p-fluorophenyl)-4-(p-nitrobenzyl)piperazine

Sources & evidence

ORD record
ord-63eae198dc2640b88a751c38c182eebf
Source dataset
uspto-grants-1979_02
Patent number
US04140775

Reaction notes

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