Hydrochloric Acid → HCID 178512450, compound

HRID 1391217Notes

Reaction equation

HRID 1391217 reaction equation
[NH:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[N:3]=[CH:2]1.CS[C:12](=[NH:14])[NH2:13].Cl>C(#N)C>[C:12]([N:6]1[CH2:7][CH2:8][C:9]2[NH:1][CH:2]=[N:3][C:4]=2[CH2:5]1)(=[NH:13])[NH2:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 51422-Methyl-2-thiopseudoureaHCID 178420865HCID 178420865, compound

Product 1

HCID 178512450HCID 178512450, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1.23 g of 4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine and 0.9 g of S-methyl-isothiourea in 15 ml of acetonitrile is refluxed for 8 h. After evaporation to dryness, the residue is treated with one equivalent of ethanolic hydrogen chloride. After cooling, 1.4 g of 5-guanyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine monohydrochloride, m.p. 310°, are collected.

Workup

  1. customAfter evaporation to dryness
  2. temperatureAfter cooling
  3. custom1.4 g of 5-guanyl-4,5,6,7-tetrahydro-imidazo-[4,5-c]-pyridine monohydrochloride, m.p. 310°, are collected

Sources & evidence

ORD record
ord-bab96641c1384480a372c3bbd31b5d5a
Source dataset
uspto-grants-1979_02
Patent number
US04141899

Reaction notes

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