Hydrochloric Acid → HCID 131711434, compound

HRID 1391307Notes

Reaction equation

HRID 1391307 reaction equation
[ClH:1].[C:2]1([N:8]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C@@H:10]3[CH2:17][N:18]([CH2:21][CH2:22][CH2:23][C:24]([O:26]CC)=[O:25])[CH2:19][CH2:20][C@@H:9]23)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>>[ClH:1].[C:2]1([N:8]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C@@H:10]3[CH2:17][N:18]([CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])[CH2:19][CH2:20][C@@H:9]23)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 131711435HCID 131711435, compound2×

Product 1

HCID 131711434HCID 131711434, compound

Procedure

10.6 grams (0.264 moles) of (±)-trans-1,3,4,4a,5,9b-hexahydro-5-phenyl-2H-pyrido[4,3-b]indole-2-butyric acid, ethyl ester, hydrochloride (the compound of Example 4) was suspended in 80 ml. of 6N hydrochloric acid and was refluxed for 20 minutes. Immediately upon cooling, a precipitate was obtained which was filtered and washed with a small quantity of water giving the title compound, m.p. 238.5°-240° C. (dec.).

Workup

  1. temperatureImmediately upon cooling
  2. customa precipitate was obtained which
  3. filtrationwas filtered
  4. washwashed with a small quantity of water giving the title compound, m.p. 238.5°-240° C. (dec.)

Sources & evidence

ORD record
ord-5bd74c47b19346a08a8f46b4352da422
Source dataset
uspto-grants-1979_02
Patent number
US04141980

Reaction notes

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