Hydroxyamine hydrochloride → HCID 136227082, compound

HRID 1391332Notes

Reaction equation

HRID 1391332 reaction equation
[CH2:1]([C:3]1[CH:17]=[CH:16][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=O)=[C:5]([OH:18])[CH:4]=1)[CH3:2].Cl.[NH2:20][OH:21]>>[CH2:1]([C:3]1[CH:17]=[CH:16][C:6]([C:7](=[N:20][OH:21])[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[C:5]([OH:18])[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 12562657(4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone

Product 1

HCID 136227082HCID 136227082, compound

Procedure

4-Ethyl-4'-fluoro-2-hydroxybenzophenone (21.0 g, 80% pure) was treated with hydroxylamine hydrochloride (24.0 g) in a manner similar to that in Example 3, to give, after recrystallisation from benzene, the title compound as a white crystalline solid (10.7 g), m.p. 130°-2° C.

Workup

  1. customto give
  2. customafter recrystallisation from benzene

Sources & evidence

ORD record
ord-f5798c2b2b0444e2b3b9151ea5c8cfa6
Source dataset
uspto-grants-1979_02
Patent number
US04141995

Reaction notes

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