Triethylamine → HCID 58890883, compound

HRID 1391458Notes

Reaction equation

HRID 1391458 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.C(N(CC)CC)C.[NH2:17][C@@H:18]([CH2:20][OH:21])[CH3:19]>C(#N)C>[Br:1][C:2]1[C:3]([NH:17][C@H:18]([CH3:19])[CH2:20][OH:21])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 80308(R)-(-)-2-Amino-1-propanolHCID 2899735-Bromo-2,4-dichloropyrimidine

Product 1

HCID 58890883HCID 58890883, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 22.8 g (100 mmol) of 5-bromo-2,4-dichloropyrimidine in 100 ml of acetonitrile is mixed at 0° C. first with 17.0 ml (125 mmol) of triethylamine and then with 9.4 g (125 mmol) of D-alaninol. The batch is stirred overnight at room temperature. The precipitate that is formed is suctioned off, washed with water, and completely dried. 21.5 g (81 mmol, corresponding to 81% of theory) of the product is obtained.

Workup

  1. customThe precipitate that is formed
  2. washwashed with water
  3. customcompletely dried
  4. custom21.5 g (81 mmol, corresponding to 81% of theory) of the product is obtained

Sources & evidence

ORD record
ord-29e9d52458dd410392b816bb112ccf74
Source dataset
uspto-grants-2008_03
Patent number
US07338958B2

Reaction notes

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