反应详情

温度

47.5 °C

50.5 g of 5-bromo-2,4-dichloropyrimidine is mixed with 133 ml of 2N sodium hydroxide solution and stirred for 50 minutes at 45-50° C. After cooling, it is acidified with 21 ml of concentrated hydrochloric acid while being cooled with ice. The precipitate is suctioned off, washed with water and a little methylene chloride and dried at 25-35° C. 17.12 g (36.9% of theory) of the product with a melting point of 136-145° C. (decomposition) is obtained.

1. temperatureAfter cooling
2. temperaturewhile being cooled with ice
3. washwashed with water
4. dry with materiala little methylene chloride and dried at 25-35° C
5. custom17.12 g (36.9% of theory) of the product with a melting point of 136-145° C. (decomposition) is obtained