Water → HCID 11959533, compound

HRID 1391847Notes

Reaction equation

HRID 1391847 reaction equation
O.Cl.[NH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1.C(N(CC)CC)C.[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22]Cl)=[CH:20][CH:19]=1.O>ClCCl>[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][N:3]2[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]2)=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 96024-Fluorobenzyl chlorideHCID 2723901Piperonylamine

Product 1

HCID 11959533HCID 11959533, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 10 mmol of piperidin-4-one hydrochloride monohydrate and 20 mmol of triethylamine, dissolved in dichloromethane, there are slowly added 10 mmol of 4-fluorobenzyl chloride; the reaction mixture is then heated at reflux of the solvent for 48 hours, with vigorous stirring. After returning to ambient temperature, water is added and then, after separation of the phases, the organic phase is dried, filtered and concentrated in vacuo to yield the expected product in the form of an orange oil.

Workup

  1. temperaturethe reaction mixture is then heated
  2. temperatureat reflux of the solvent for 48 hours, with vigorous stirring
  3. customAfter returning to ambient temperature
  4. customafter separation of the phases
  5. customthe organic phase is dried
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a2a76171623847068c56d311f84352a1
Source dataset
uspto-grants-2008_03
Patent number
US07339061B2

Reaction notes

Loading…