1-benzyl-1H-indole-3-carbaldehyde → HCID 4637679, compound

HRID 1392268Notes

Reaction equation

HRID 1392268 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH:17]=O)=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:20][OH:21]>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([CH:17]=[N:20][OH:21])=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2621041-benzyl-1H-indole-3-carbaldehydeHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 4637679HCID 4637679, compoundYield 60%

Procedure

1-Benzyl-1H-indole-3-carbaldehyde oxime (1.752 g, 60%) was prepared from 1-benzyl-1H-indole-3-carbaldehyde and hydroxylamine hydrochloride using a procedure similar to Step 6 of example 1. 1H NMR (400 MHz, DMSO-d6); δ 11.30 (s, 1H), 8.40 (s, 1H), 7.88 (d, 1H), 7.80 (s, 1H), 7.50 (d, 1H), 7.22 (m, 7H), 5.50 (s, 2H).

Sources & evidence

ORD record
ord-c1e1fc4cd680475d866f9b1f490e2d85
Source dataset
uspto-grants-2008_03
Patent number
US07342039B2

Reaction notes

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