Methyl bromoacetate → Methyl (4-nitro-1-imidazolyl)acetate

HRID 1392443Notes

Reaction equation

HRID 1392443 reaction equation
[N+:1]([C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)([O-:3])=[O:2].[CH3:9][O:10][C:11](=[O:14])[CH2:12]Br>>[CH3:9][O:10][C:11](=[O:14])[CH2:12][N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1

Participants

3

Reactant 2

HCID 60984Methyl bromoacetateHCID 178526856HCID 178526856, compound

Product 1

HCID 3103698Methyl (4-nitro-1-imidazolyl)acetate

Procedure

4-nitroimidazole was alkylated with bromo-acetic acid methyl ester to provide the title compound: 1H NMR (400 MHz) 3.82 (s, 1H), 4.80, (s, 2H), 7.47 (d, 1H, J=1.7 Hz), 7.84 (d, 1H, J=1.7 Hz); gc/ms m/z 185 (M).

Sources & evidence

ORD record
ord-29b34441757645559e47a6f66061c98b
Source dataset
uspto-grants-2008_03
Patent number
US07342118B2

Reaction notes

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