反应详情

Benzenesulfonamide (638 mg) and 4,5-bis(bromo-methyl)thiazole (M. Al. Hariri, O. Galley, F. Pautet, H. Fillion, Eur. J. Org. Chem., 1998, 593-594.) (1.10 g) were dissolved in N,N-dimethylformamide (10 ml), sodium hydride (60% in oil, 357 mg) was added at a time, and the mixture was stirred at room temperature for 3 hours. Water and methylene chloride were added to conduct liquid separation. After the resultant organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off, and the residue was purified by column chromatography on silica gel (methylene chloride:ethyl acetate=9:1) to obtain the title compound (137 mg).

1. customliquid separation
2. dry with materialAfter the resultant organic layer was dried over anhydrous sodium sulfate
3. distillationthe solvent was distilled off
4. customthe residue was purified by column chromatography on silica gel (methylene chloride:ethyl acetate=9:1)