反应详情

4-Chlorobenzaldehyde (2.81 g) was dissolved in methylene chloride (300 ml), and carbon tetrabromide (13.3 g) and triphenylphosphine (21.0 g) were added to stir the mixture at room temperature for 90 minutes. After insoluble matter deposited was removed by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=20:1) to obtain the title compound (5.54 g).

1. customAfter insoluble matter deposited was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=20:1)