Potassium Carbonate → HCID 69310778, compound

HRID 1392935Notes

Reaction equation

HRID 1392935 reaction equation
C([O:4][C@@H:5]1[CH:11]=[CH:10][C@H:9]([N:12]2[C:16]3[N:17]=[C:18]([S:31][CH2:32][CH2:33][CH3:34])[N:19]=[C:20]([NH:21][C@@H:22]4[CH2:24][C@H:23]4[C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[C:15]=3[N:14]=[N:13]2)[C:6]21[CH2:8][CH2:7]2)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:32]([S:31][C:18]1[N:19]=[C:20]([NH:21][C@@H:22]2[CH2:24][C@H:23]2[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:15]2[N:14]=[N:13][N:12]([C@@H:9]3[C:6]4([CH2:7][CH2:8]4)[C@H:5]([OH:4])[CH:11]=[CH:10]3)[C:16]=2[N:17]=1)[CH2:33][CH3:34]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69314748HCID 69314748, compound

Product 1

HCID 69310778HCID 69310778, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the product of step g) (0.5 g) in methanol (10 ml) was added potassium carbonate (0.5 g) and the resulting suspension was stirred at ambient temperature for 2 hours. The reaction mixture was absorbed onto silica and purified by chromatography (SiO2; 3:1 isohexane:ethyl acetate) to give the subtitle compound (0.4 g).

Workup

  1. customThe reaction mixture was absorbed onto silica
  2. custompurified by chromatography (SiO2; 3:1 isohexane:ethyl acetate)

Sources & evidence

ORD record
ord-37ba9b618384441c923196a26b2272a8
Source dataset
uspto-grants-2008_03
Patent number
US07345047B2

Reaction notes

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