Methanol → HCID 56660575, compound

HRID 1393001Notes

Reaction equation

HRID 1393001 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[CH:7]3[C:14]4([CH2:15][CH2:16][C:5]=2[CH:4]=1)[CH:10]([CH2:11][NH:12][CH2:13]4)[CH2:9][CH2:8]3.[CH3:19]O.[OH-].[NH4+]>ClCCl>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[CH:7]3[C:14]4([CH2:15][CH2:16][C:5]=2[CH:4]=1)[CH:10]([CH2:11][N:12]([CH3:19])[CH2:13]4)[CH2:9][CH2:8]3

Participants

5

Reactant 3

HCID 887MethanolHCID 14923Ammonium HydroxideHCID 67424147HCID 67424147, compound2×

Product 1

HCID 56660575HCID 56660575, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the procedure of Example 1B but replacing the resultant compound of Example 1A (Compound 1A-a) with the resultant compound of Example 1A(Compound 1A-b), provided, after silica gel chromatography using 5% methanol and 0.5% ammonium hydroxide in dichloromethane, 102.0 mg (88.5%) of the title compound as a white solid.

Workup

  1. customprovided

Sources & evidence

ORD record
ord-ae24790b24b3482daf8313f47f8d64b3
Source dataset
uspto-grants-2008_03
Patent number
US07345034B2

Reaction notes

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