1-Hydroxybenzotriazole → HCID 67424004, compound

HRID 1393011Notes

Reaction equation

HRID 1393011 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:16][C:15]2[C:6]([CH3:25])([CH:7]3[CH:12]([CH2:13][CH:14]=2)[CH:11]2[CH2:17][CH2:18][CH:19]4[CH:20]([CH3:24])[N:21]([CH3:23])[CH2:22][C:10]24[CH2:9][CH2:8]3)[CH2:5][CH2:4]1.[C:26]([N:33]([CH3:41])[C@@H:34]([C:38]([OH:40])=O)[CH:35]([CH3:37])[CH3:36])([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27].Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1>C1COCC1.ClCCl>[C:29]([O:28][C:26](=[O:27])[N:33]([CH3:41])[CH:34]([C:38](=[O:40])[N:2]([CH3:1])[CH:3]1[CH2:16][C:15]2[C:6]([CH3:25])([CH:7]3[CH:12]([CH2:13][CH:14]=2)[CH:11]2[CH2:17][CH2:18][CH:19]4[CH:20]([CH3:24])[N:21]([CH3:23])[CH2:22][C:10]24[CH2:9][CH2:8]3)[CH2:5][CH2:4]1)[CH:35]([CH3:36])[CH3:37])([CH3:30])([CH3:31])[CH3:32]

Participants

7

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 551434KurchineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 7018800Boc-N-methyl-D-Valine

Product 1

HCID 67424004HCID 67424004, compoundYield 72.3%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of compound 7B (240 mg, 0.702 mmol), Boc-N-methyl-D-valine (176 mg, 0.762 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (208 mg, 1.085 mmol), 1-hydroxybenzotriazole (146 mg, 1.085 mmol), dichloromethane (5 mL) and THF (2.5 mL) was stirred at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was dissolved in minimum amount of dichloromethane and purified on silica gel column, which was eluted with 0.5% ammonium hydroxide and 5% methanol in dichloromethane to give the desired product (282 mg, 72% yield).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue was dissolved in minimum amount of dichloromethane
  3. custompurified on silica gel column, which
  4. washwas eluted with 0.5% ammonium hydroxide and 5% methanol in dichloromethane

Sources & evidence

ORD record
ord-50d8f7b91f2542d2b02ba0e75d4a9d9a
Source dataset
uspto-grants-2008_03
Patent number
US07345034B2

Reaction notes

Loading…