反应详情

A 4 N solution of hydrogen chloride in ethyl acetate (0.400 ml, 1.60 mmol) was added to a solution of 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-1) (200 mg, 0.486 mmol) in chloroform (0.3 ml). The solvent was evaporated under reduced pressure, and the precipitated solid was washed with ethyl acetate and filtered off. The obtained crude crystals were recrystallized from 2-butanone (5.0 ml) to give 94 mg (43%) of the titled compound.

1. customThe solvent was evaporated under reduced pressure
2. washthe precipitated solid was washed with ethyl acetate
3. filtrationfiltered off
4. customThe obtained crude crystals
5. customwere recrystallized from 2-butanone (5.0 ml)