Methyl iodide → HCID 10272450, compound

HRID 1393573Notes

Reaction equation

HRID 1393573 reaction equation
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:17][CH2:18][O:19][CH2:20][C:21]([OH:23])=[O:22])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:30](=O)([O-])[O-].[Cs+].[Cs+].CI>CN(C)C=O>[CH3:30][O:22][C:21](=[O:23])[CH2:20][O:19][CH2:18][CH2:17][O:16][C:13]1[CH:14]=[CH:15][C:10]2[N:9]=[C:8]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:11]=2[CH:12]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 21938042HCID 21938042, compound

Product 1

HCID 10272450HCID 10272450, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

35 mg of 2-[2-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]ethoxy]acetic acid was dissolved in 0.4 ml of N,N-dimethylformamide and mixed with 29 mg of cesium carbonate and 50 μl of methyl iodide. It was stirred for 20 hours, then concentrated by evaporation in a vacuum and chromatographed on silica gel.

Workup

  1. concentrationconcentrated by evaporation in a vacuum
  2. customchromatographed on silica gel

Sources & evidence

ORD record
ord-9bc1690be3154cb0bff16e02c4db285c
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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