反应详情

The product from Example 1 Step (b) (10 g) was dissolved in DMF (50 ml) and triethylamine (14.8 ml) was added. tert-Butyl 3-bromopropylcarbamate (10 g) was then added and the solution stirred at room temperature for 24 hrs. The solvent was evaporated and the resulting solid dissolved in ethyl acetate and water were added, the organic phase separated, dried, filtered and evaporated to a solid (17.51 g).

1. customThe solvent was evaporated
2. dissolutionthe resulting solid dissolved in ethyl acetate
3. additionwater were added
4. customthe organic phase separated
5. customdried
6. filtrationfiltered
7. customevaporated to a solid (17.51 g)