Acetic Acid → HCID 59681882, compound

HRID 1394164Notes

Reaction equation

HRID 1394164 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[O:17]1[C:21](=O)[CH2:20][NH:19][C:18]1=[O:23].N1CCCCC1.C(O)(=[O:32])C>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10](/[CH:11]=[C:21]3/[C:20](=[O:32])[NH:19][C:18](=[O:23])[O:17]/3)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 75136Oxazolidine-2,5-dioneHCID 38568024-(4-Fluorophenoxy)benzaldehyde

Product 1

HCID 59681882HCID 59681882, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The title compound was prepared by reacting 4-(4-fluorophenoxy)benzaldehyde (from Step A in Example 1) with oxazolidine-2,5-dione in toluene in the presence of piperidine and acetic acid with continuous removal of water, as described in Step B of Example 1. The crystalline product collected was washed with petroleum ether on the filter and dried in vacuo.

Workup

  1. customwith continuous removal of water
  2. customThe crystalline product collected
  3. washwas washed with petroleum ether on the
  4. filtrationfilter
  5. customdried in vacuo

Sources & evidence

ORD record
ord-ab0c74f6c3ca4698b2b17f6384e78c7e
Source dataset
uspto-grants-2008_03
Patent number
US07348348B2

Reaction notes

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